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KMID : 1123920040180010194
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Korean Journal of Oriental Physiology and Pathology
2004 Volume.18 No. 1 p.194 ~ p.199
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Effect of Cheonmabanhwa-tang on the Cerebral Hemodynamics in Rats
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Yang Gi-Ho
Jung Hyun-Woo
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Abstract
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Cheonmabanhwa-tang(CBT) has been used in the Oriental Medicine for many centuries as a therapeutic agent for dizziness due to Poong-Dam. This study was designed to investigate whether CBT has a cytotoxicity in vitro, and affects the cerebral hemodynamics [regional cerebral blood flow(rCBF), pial arterial diameter(PAD), and mean arterial blood pressure(MABP)) in normal and cerebral ischemic rats. The changes of rCBF were determinated by laser-doppler f1owmeter(LDF), and the change of PAD was determinated by video-microscopy. The results in normal rats were as follows: CBT had no cytotoxicity in neuronal cells. CBT significantly increased rCBF. MABP and PAD in a dose-dependent manner, respectively. Both rCBF and PAD were significantly and stably increased by CBT(10 mg/kg, i.p.) during the period of cerebral reperfusion. which contrasted with the findings of rapid and marked increase in control group. In conclusion, it is suggested that CBT causes a diverse effect on cerebral hemodynamics thereby has an anti-ischemic action.
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KEYWORD
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Cheonmabanhwa-tang(天麻半夏湯), cerebral hemodynamics, laser-doppler flowmeter, cerebral ischemia
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